منابع مشابه
cardiac damage in left breast cancer patients
Introduction :Today there is general awareness of the potential damage to the heart in left- sided (more than in rightsided) breast cancer radiotherapy. Material & Method: Historical changes in tumor and heart doses are presented here along with the impact of different RT techniques and volumes. Results: Individual and pharm...
متن کاملDNA Damage Response and Breast Cancer: An Overview
The cells throughout the human body are constantly subjected to both internal forces and external insults that cause damage to their DNA. This damage to the DNA can be harmful to the overall integrity of the cell and the ability for replication. Accurate transmission of genetic information from one cell to its progeny is dependent upon mechanisms within the cell to monitor any defects within it...
متن کاملBreast cancer susceptibility and the DNA damage response.
Breast cancer is a disease caused by a complex combination of genetic and environmental factors. It is one of the most common types of cancer affecting women in the Western world. In 2004 in the United States, it is estimated that more than 200,000 new cases of breast cancer will be diagnosed and over 40,000 will die of this disease. Linkage analysis of families with a high risk of breast cance...
متن کاملHeadliners: Breast Cancer: Repair of DNA Damage Differs Between Sisters With and Without Breast Cancer
Development of methods that will allow exogenous imposition of inheritable gene-specific methylation patterns has potential application in both therapeutics and in basic research. An ongoing approach is the use of targeted DNA methyltransferases, which consist of a fusion between gene-targeted zincfinger proteins and prokaryotic DNA cytosine methyltransferases. These enzymes however have so far...
متن کاملNUCL EAR DNA CONTENT AND DNA PLOIDY ANALYSIS IN BREAST CANCER
To investigate the patterns of DNA ploidy and proliferating activity in breast cancer and relate them to other prognostic factors, paraffin blocks of 53 cases of breast carcinoma were studied. Cancer cells obtained by mechanical tissue disaggregation were examined for DNA content, ploidy and S-phase fraction. DNA assay was done using a CAS interactive image analyzing system. All of the cas...
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ژورنال
عنوان ژورنال: World Journal of Clinical Oncology
سال: 2011
ISSN: 2218-4333
DOI: 10.5306/wjco.v2.i9.329